Human Growth Hormone Market Segmentation Application, Technology & Market Analysis Report
Human body naturally
produces growth hormones in the pituitary gland. Human growth hormone
is a peptide hormone, which stimulates growth, cell reproduction, and
cell regeneration in humans as well as animals. Growth hormone is
stored and secreted by somatotropic cells within the lateral wings of
anterior pituitary gland. Functions of growth hormones include
increased height during childhood, increases calcium retention,
strengthens and increases mineralization of the bone, increases
muscle mass through sarcomere hypertrophy, promotes lipolysis,
increases protein synthesis, stimulates growth of all internal organs
excluding the brain, plays a vital role in homeostasis, reduces
uptake of glucose by liver, stimulates the immune system, and
increases DE iodination of T4 to T3. Excess secretion of growth
hormones causes pituitary tumor, which consists of somatotroph cells
of the anterior pituitary. These somatotroph cells are benign and
grow slowly, producing excess of growth hormones. This causes
headaches, impaired vision by pressure caused on optic nerves,
deficiency of other hormones secreted by pituitary gland, and
thickening the bones of jaw, toes, and fingers, which eventually
results in heaviness of jaws and increase in size of digits called as
acromegaly. Acromegaly causes pressure on nerves, muscle weakness,
and reduced sexual function. The deficiency of growth hormone causes
failure in growth, increase in osteoclast activities, weakening of
bones, trauma, increase in fat mass, and decrease in muscle mass.
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Human Growth
Hormone Market Drivers:-
Major driver for
human growth hormone market is new mergers and acquisitions. For
instance, in 2014, Pfizer Inc., a U.S.-based pharmaceutical company,
merged with OPKO Health Inc., a U.S.-based company, to develop a long
acting growth hormone (hGH-CTP) and to bring innovative treatments
for growth hormone deficient patients. hGH-CTP is more convenient, as
the patients need to take just one injection in a week rather than
daily doses. hGH-CTP has an orphan drug designation in the U.S. and
Europe for adults and children with growth hormone deficiency.
Robust pipeline is
also expected to support the growth in human growth hormone market
size. For instance, Somapacitan sponsored by Novo Nordisk A/S, a
Denmark-based company, completed phase 3 clinical trials in 2017.
This drug is used for the treatment of growth hormone deficiency in
adults. MOD-4023 sponsored by Opko Biologics, an Israel-based
company, completed phase 2 clinical trials in 2015. High prevalence
of growth hormone deficiency is another factor boosting growth of
human growth hormone market. According to a survey conducted by the
National Organization for Rare Diseases (NORA) in 2015, over 10,000
children and 50,000 adults have growth hormone deficiency in the U.S.
However, strict
rules and regulations for the use of human growth hormone by athletes
and sports professionals is expected to restrain growth of human
growth hormone market. The Food and Drug Administration (FDA) and the
International Olympic Committee had banned the use of human growth
hormone for sports professionals in 2006.
Human Growth
Hormone Market Regional Analysis:-
North America is
expected to hold dominant position in the global human growth hormone
market due to new biosimilar approvals by Health Canada for
biosimilar of human growth hormone drugs. For instance, in 2015,
Health Canada approved the first generic biological called as
PROmnitrope. PROmnitrope is a recombinant human growth hormone used
to treat deficiency of growth hormone in adults as well as children.
This can encourage new generic version of drugs, thereby fueling the
human growth hormone market growth.
Europe human growth
hormone market is expected to witness significant growth due to
mergers and acquisitions. For instance, in 2017, Ferring
Pharmaceuticals S.A., a pharmaceutical company, acquired a product
i.e. Zoma Jet of Antares Pharma Inc, a pharmaceutical company. Zoma
Jet is a needle free auto injectable device. Ferring Pharmaceuticals
S.A acquired Zoma Jet in order to increase use of Zomacton
(Injectable somatropin hGH). Zoma Jet is used to deliver Zomacton for
the treatment of growth hormone deficiency in children and Turner’s
syndrome in girls. By acquiring the injectable device Zoma Jet, would
eventually lead to increase in use of the drug, Zomacton, which will
further encourage Ferring Pharmaceuticals to develop better treatment
options for growth hormone deficiency, thereby resulting in growth of
the human growth hormone market. Asia Pacific is expected to grow
over the forecast period due to robust pipeline. For instance, Cinna
Tropin sponsored by Cinnagen, an Iran-based company, completed phase
3 clinical trials in 2017. This drug is used to treat idiopathic
short stature in children and adults.\
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Human Growth
Hormone Market Key Players:-
Key players
operating in the global human growth hormone market include Pfizer
Inc., Genetech Inc., Merck & Co., Eli Lilly And Company, Novo
Nordisk, Sandoz International GmbH, Ferring Holding SA, and Ipsen.
Human Growth
Hormone Market Taxonomy:-
By Application
Growth Hormone
Deficiency
Idiopathic short
stature
Prader-Willi
Syndrome
Turner Syndrome
Others
By Route of
Administration
Oral
Intravenous
Subcutaneous
Intramuscular
By Distribution
Channel
Hospitals
Retail
Pharmacies
Online
Pharmacies
By Region
North America
Europe
Latin America
Asia Pacific
Middle East
Africa
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